Prevent Disk Sleep FAQ

Use the top menu: Options -> Auto start at Start-up

If you run the program as Administrator (elevated), you can't see network drives (NAS). This is because the mapped drives were created under a login different from the administrator login. If you want to use mapped drives, the application must be run as current user.

That would depend on the age of the hard drive and the brand. Today's hard drives are made for 24/7 usage. Having said that, HDD manufacturers recommend “unplugging the drive when not in use, although it is safe to keep a hard drive running.”